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    • HOME
    • ABOUT US
    • AI and Antibody Drug R&D
    • TUMOR IMMUNE THERAPY
      • Introduction
      • Cancer Immunotherapy Type
    • NBRL CELL & GENE DRUG R&D
      • Introduction
      • NBRL Cell & Gene Drug
      • Intrabody Development
      • Next Step Development
    • Nanobody Drug R&D
    • Alzheimer’s Disease
    • CONTACT US
  • HOME
  • ABOUT US
  • AI and Antibody Drug R&D
  • TUMOR IMMUNE THERAPY
    • Introduction
    • Cancer Immunotherapy Type
  • NBRL CELL & GENE DRUG R&D
    • Introduction
    • NBRL Cell & Gene Drug
    • Intrabody Development
    • Next Step Development
  • Nanobody Drug R&D
  • Alzheimer’s Disease
  • CONTACT US

Novel Anti-Alzheimer Therapeutics Discovery and Development

Alzheimer Disease (AD)– Research and Development

Alzheimer's drug development pipeline and research overview for 2022.

  

Alzheimer disease (AD) is uniquely characterized amyloid dysregulation (Amyloid Aggregate > Clear). The emerging paradigm: Target  Aβ Oligomers

The Novel anti-AD antibody-based Drugs Development

Diagram explaining amyloid precursor protein processing and Alzheimer's disease brain changes.

Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases 

Developing Novel Anti-Aβ, tau and α-Syn

The innovative anti- Aβ therapeutic Bispecific antibody candidates development

Graph shows progression and overlap of neurodegenerative proteinopathies over time.

 Developing anti Aβ, Tau and α-Syn bispecific and multi- therapeutic antibody and Fc fusion proteins candidates 

The innovative anti- Aβ therapeutic Bispecific antibody candidates development

The innovative anti- Aβ therapeutic Bispecific antibody candidates development

The innovative anti- Aβ therapeutic Bispecific antibody candidates development

 The several  Anti- Aβ therapeutic Bispecific antibody candidates have been selected

Development of multi- targets therapeutic candidates for AD

The innovative anti- Aβ therapeutic Bispecific antibody candidates development

Development of enhancing the BBB infiltration therapeutic candidates

The  multi- targets therapeutic candidates for AD  have been generated

Development of enhancing the BBB infiltration therapeutic candidates

The innovative anti- Aβ therapeutic Bispecific antibody candidates development

Development of enhancing the BBB infiltration therapeutic candidates

The candidates of enhancing the BBB infiltration therapeutics   for AD  have been selected

Development of Stem cells/iPSC for Treatment of Alzheimer’s

 NBRLBoston is undergoing development of stem cell/iPSC based cell therapy for  the treatment of Alzheimer neurodegeneration diseases

AI supporting antibody drug R&D for brain disease

 AI-driven optimization of anti-amyloid antibody to minimize plasma binding 

 AI-driven optimization of anti-TfR1 nanobody antibody to improve antibody cross BBB

generated anti-amyloid anft-TfR1 BsAb have showed tens folds antibody in brain tissue in vivo evaluation


 The selected lead candidates ready for license-out, co-development, and strategic pharmaceutical partnerships. 

For more information regarding our products in development, feel free to reach out to us. 



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